No issues at all driving cars. I own several vehicles, and the Raptor is currently my only truck, but have owned several trucks over the years including an F450. For daily driving around town, I prefer the Raptor. There are so many unqualified drivers on the roads these days, and few seem to even pay attention to stop signs and red lights anymore. Sharing the road with a truck tends to make other drivers a little more cautious, alert and frankly submissive in their driving. That was especially prevalent when I was driving the F450. Also, in a fender bender, most trucks will soak up an impact with very little damage, not to mention pot holes. In snowy conditions, when bad drivers become even worse, a truck is almost a necessity over a car.
While fine for cruising, I typically don't enjoy the Raptor or any other truck on the highway. They are not very stable at higher speeds, and the brakes are a bit lacking, to say the least.
For spirited on-road driving, the Raptor isn't much better than a sports car is off-road. That is of course to be expected.
Switching back and forth can be a bit awkward for a few minutes, but you can adjust quickly. I'd say its on-par with often switching between vehicles with automatic and manual transmissions.