Great info for getting into the cab. But if you're items (lights for example) are outside the cab in the bed and you're trying to route the wires to the upfitter wire leads available in the engine compartment, why route the wires into the cab? Seems like it would be easier to stay outside the cab and run inside or along the frame to get to the upfitter wires in the engine compartment.
In my recent experience, it was a pita to run the wires inside the passenger side rail. Although they have small holes, you have to do it in small sections, just to get to the hood area. (using reach tool, or wire snake)
I also ran with an issue with the cross welds towards the center, I couldnt get my 7awg wire to fit through, so I had to run part of my wiring out the center and in again. (This was a thick wire for my dual battery setup)
If you have bed/ roll bar light, its easier route the wire from top, in between the bed and cab area and into this hole imho. Its also in close proximity to the bed access hole.