On these trucks the hub assembly interfaces with the Integrated Wheel End (IWE). It is critical that the IWE is compressed with vacuum during hub installation to avoid damage to either component. Once the axle shaft is inserted into the wheel bearing, the threaded end needs to be measured for depth within the wheel bearing. It it's too shallow, the splines are not aligned and damage will occur. If CV depth is correct, the axle nut then needs to be torqued to 30 lb.ft. That is of course much lower than a typical axle nut torque spec, which is often 150-300 lb.ft.
^ comment from FordTechOne concerning the wheel hubs. Seems like all of you haven't ran into issues yet, right? Thinking about doing mine soon.