ummm - you do realize everyone running a tune alone on these trucks is DD'ing a (roughly) 500-550 bhp 560-620tq truck to begin with right? I'm running a gearhead tune & I wouldn't be surprised if it added another 75hp to the rear wheels. There are dyno sheets out there showing mild bolt-on Raptors w/ tunes making 450-475whp & 540-570rwtq - that translates into around 550 @ motor. I don't even know if my truck notices the extra power, I haven't told it yet, but it seems to shrug it off just fine lol!!
As other mentioned, you have 600hp Gen 1's out there w/ the weaker frames/trannies & they're doing OK, I'd say the platform can "handle" it - but put it to any kind of good use on road or off not so sure about that
Im talking about serious power and over doing it possibly. Unless the truck was very capable of handling it from the design. Somewhere like 700-800HP