I have the Ford OEM rubber bed mat and it works fantastic and is easy to remove if necessary. I generally wait and if the bed starts showing wear after a couple of years Linex (or equivalent) is the way to go. Can't stand that HUGE FORD oval they put in the front bed wall with the oem spray in liner....
Another thing that works very well and is super versatile is the OEM foldable bed extender. Folds out of the way when not in use and you can use one or both sides and flip it forward to have a nice cargo area in rear of bed so things wont roll around. I use one side all the time for propane tank refill...just leave in forward tucked position and open it and a tank fits perfectly inside (same deal with nursery runs), etc. Of note, the new bed extender kit come with two sizes of the rubber "feet", longer ones if you don't have a bed mat and shorter ones that work with the OEM rubber mat. Great set up and (IMO) well worth the $$'s I use mine all the time, you can bungee lumbar, etc. to it as well! Very clever design on Ford's part!