Back to my dealer days.
Mostly did Diesel repairs so most my memories are of that.
Here in Utah 70mph is speed limit when freeway/interstate goes through a city with 80 being limit in more open areas. But we drive 10 over all the time. Pretty easy to do 95mph from St George to Provo.
We have surface streets that are 55.
Anyway. On the 7.3 and 6.0 diesels. For every 5mph over 65 fuel mileage would drop 2mpg.
Ford also had a chart at the time listing all kinds of vehicle options and modifications and how they affected mpg.
Every inch of lift was .5 mpg, towing mirrors were .25 mpg less than the little paddle mirrors. 4x4 was 4mpg less than 4x2. Running boards were .3 mpg loss. Tires were huge difference also
So take a 2002 7.3 4x2 truck and at 65 it could get 25ish mpg.
Add 4x4 (which I have) now down to 21ish. Now lift 4 inches, add running boards, have factory tow mirrors, drive 80, add 35x12.5 tires and BOOM my psd gets 13 - 11 mpg.
Just examples I know of.