Absolutely I worry about road noise. These are sophisticated vehicles, why would you ruin a truck that runs quietly and fatigue free on the interstate with loud ass tires, that are totally unneccasary? It is a desert truck, the ko2 suite it perfectly, excellent speed rating, good ride quality, they are even good in the snow. Noise conscientiousness is exactly why I went with corsa exhaust instead of glasspacks. I have loud vehicles, the wind, engine and tire noise from my jeep at 65 is enough to keep me from talking to the passenger, you pretty much have to scream so it isn't worth it. My f150 will straight wear you out on a long cruise: between the noise of the 80mm turbo constantly singing and the 460 breathing out 5" exhaust it can be numbing, add that to having enough power to put you sideways on a dry interstate the fatigue is immense. My mustang is set up for road race, hitting a bump on the highway is similar to being punched in the spine, the whipple always wants to go and even with Corsa's on it it is noisy. Once you have done that some you want a vehicle you can actually relax in, the raptor rides good, steers good and is quiet until asked to make noise, I can do a thousand miles in it in a day and not feel beat to hell the next morning, I treasure that.
OP, avoid load range E, it will stiffen the ride considerably and you will never, ever use the weight capacity in a raptor. Run range C or D, you will be faster off road at speed and more comfortable in the 'hood,