SC is water to air cooling for the IC and there's a limiting factor to how big the IC can be,
so a Tune would not be needed unless you want extra 15 to 30 rwhp out of a upgrade.
Whipple did have two version of the IC for the 6.2L Raptor for a short time, now they only offer the bigger IC.
There was a 50 HP difference between the two ICs.
What's important to SC is the the Heat Exchanger,
there you can go much bigger and a tune is not needed but again if want all the HP gain a retune would be needed.
With the Turbo setup it's air to air IC (no HE). The hot compressed air from the turbos pass through inside the IC.
So if you go bigger with the IC you can increase air flow and produce colder air.
But if the tune is not calibrated for those gains you kind of wasted your money on the upgraded IC.
Other than some help with heat soak.
Hope that helps, you really have do your research and ask all these questions.