I disagree. As you mentioned, there are millions out there so bringing up the 5 you know is not a sufficient representation of the population.
Turbocharged engines have lower reliability (in comparison to their naturally aspirated counterparts) due to the increased temperatures at which they operate at, the increased pressures inside the combustion chamber, intake/exhaust manifolds, the more sophisticated control technologies (and associated sensors they are dependent on) and the basic statistics of having more parts, each of which has its chance own chances of failure.
There are far more “flight critical” parts on any turbo engine. These are the parts that are required to work correctly for the engine to function. More parts = more chances of having any one part fail.
Turbocharged engines create more heat which leads to higher temperatures. Operating at higher temperatures in general degrades material properties and will cause them to fail earlier every time (except for some high nickel super alloys). “Earlier” may still be at 200,000 miles or more. Just stating that it’s earlier than the same part that is not exposed to such extreme temperatures. For example, I have the spec for A-286 pulled up and it shows that the yield strength drops by 35% at just 1200F. I have seen EGT’s over 1600F on my turbo Jeep.
Also, repairs on turbocharged engines are likely to cost more than NA engines. For example, my buddy’s 2015 3.5EB had the exhaust manifold gasket blow out. It was found that the exhaust manifold had warped. This is due to the higher temperatures and pressures that turbo engines run at. Repairing it required removing the turbocharger on that side as well. A NA engine is less likely to have this happen and if it happens, it’s not nearly as critical to get it fixed since it’s not feeding in to a turbine.
Engines today are very reliable so even if you pick an unreliable design, chances are that it will still not fail on you, at least for a while.
After all, if the 3.5 was as reliable as any NA engine we would see it being used in many other places (e.g heavy duty trucks, work trucks, etc.)
Having said all this, I’m still A huge proponent of the 3.5EB but there is no getting around the numbers and the physics that it is less reliable than an equivalent naturally aspirated engine.
It sounds like you're more of a critic than a proponent. Do you own one by chance?
You discredited @goblues38 personal experience as anecdotal, and then brought up "your buddies" 2015 3.5 as evidence. You can't have it both ways.
You are making the assumption that the necessary engineering was not incorporated to ensure that these engines remain reliable while being turbocharged. All Ford engines, as with most OEMs, must pass severe durability testing whether they are N/A or forced induction. This isn't the aftermarket; they can't just throw a turbo setup on and worry about the durability later.
You may not be familiar with the Terminator 4.6 that came out in the 03/04 Cobra, but they couldn't hold them together with the off the shelf powdered metal connecting rods available at the time. The engine would make it through hours worth of maximum output testing, and then grenade. They ended up going with Manley Forged H-beam rods in order to pass durability testing, regardless of the fact that each rod cost 7 times more than the standard one. Durability testing has become more, not less, stringent since then with the increased duty cycle of trucks and the increased capability.
The 3.5 is not used in HD applications because it's not designed for HD applications. It's a 1/2 ton truck engine that can reliably tow up to 13,200lbs, just as it was tested for. It's not designed to tow 20,000 or 30,000lbs like the physically large HD cast iron gas and diesel engines are.