Wind resistance increases exponentially with speed, so mileage drops quickly as you speed up even a small amount. I don't go faster than 80, even when the limit is 80 or 85. That's plenty fast in a top-heavy three ton rig with all the weight over the front axle. It's probably too fast, but on a straight interstate, it's hard to go slower. So long as I don't have to do anything radical like turn or hit the brakes, it's OK. Turning and braking hard at the same time? It's not OK. Ask me how I know.
Besides the quality of your last fill, elevation, temperature, and humidity have an effect. High elevation, high temperature, and low humidity means thin air. When it weighs less, it takes less effort to push it aside and mileage goes up a mile or two per gallon.